Cells are continuously exposed to potentially dangerous compounds.
Progressive accumulation of damage is suspected to contribute to
neurodegenerative diseases and aging, but the molecular identity
of the damage remains largely unknown.
We have recently discovered that PARK7, an enzyme mutated in
hereditary Parkinson's disease, prevents damage of
proteins and metabolites caused by a metabolite of glycolysis.
Currently, we are trying to reveal the connection between
this type of damage and neurodegeneration.
We hope that a better understanding of this link
will eventually allow for the development of therapeutic approaches.