Selected Publications:
Heremans IP, Caligiore F, Gerin I, Bury M, Lutz M, Graff J, Stroobant V, Vertommen D, Teleman AA, Van Schaftingen E, Bommer GT (2022). Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite. Proc Natl Acad Sci U S A. 119(4):e2111338119. doi: 10.1073/pnas.2111338119.
Ury B, Potelle S, Caligiore F, Whorton MR, Bommer GT (2021). The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi. J Biol Chem. 296:100789. doi: 10.1016/j.jbc.2021.100789.
Dewulf JP, Paquay S, Marbaix E, Achouri Y, Van Schaftingen E, Bommer GT (2021). ECHDC1 knockout mice accumulate ethyl-branched lipids and excrete abnormal intermediates of branched-chain fatty acid metabolism. J Biol Chem. 297(4):101083. doi: 10.1016/j.jbc.2021.101083.
Bommer GT, Van Schaftingen E, Veiga-da-Cunha M (2020). Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis. Trends Biochemical Sciences. 45(3):228-243. doi: 10.1016/j.tibs.2019.07.004.
Gerin I, Ury B, Breloy I, Bouchet-Seraphin C, Noel G, Bolsee J, Halbout M, Graff J, Vertommen D, Muccioli GG, Seta N, Grahn A, Van Schaftingen E, Bommer GT (2016). ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol-phosphate onto a-dystroglycan. Nature communications 7(11534. doi.
Collard F, Baldin F, Gerin I, Bolsee J, Noel G, Graff J, Veiga-da-Cunha M, Stroobant V, Vertommen D, Houddane A, Rider MH, Linster CL, Van Schaftingen E, Bommer GT (2016). A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Nature chemical biology 12(601-607. doi: 10.1038/nchembio.2104.
Publications:
1. Maccioni L, Loriot A, Dewulf J, Bommer G, Horsmans Y, Lanthier N, Leclercq I, Schnabl B, Stärkel P (2022). Duodenal CD8+ T resident memory cell apoptosis contributes to gut barrier dysfunction and microbial translocation in early alcohol-associated liver disease in humans. Aliment Pharmacol Ther. 56(6):1055-1070. doi: 10.1111/apt.17177.
2. Caligiore F, Zangelmi E, Vetro C, Kentache T, Dewulf JP, Veiga-da-Cunha M, Van Schaftingen E, Bommer G, Peracchi A (2022). Human cytosolic transaminases: side activities and patterns of discrimination towards physiologically available alternative substrates. Cell Mol Life Sci. 79(8):421. doi: 10.1007/s00018-022-04439-3.
3. Johanns M, Corbet C, Jacobs R, Drappier M, Bommer GT, Herinckx G, Vertommen D, Tajeddine N, Young D, Messens J, Feron O, Steinberg GR, Hue L, Rider MH (2022). Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators. Biochemical J. 479(12):1317-1336. doi: 10.1042/BCJ20220170.
4. Dewulf JP, Martin M, Marie S, Oguz F, Belkhir L, De Greef J, Yombi JC, Wittebole X, Laterre PF, Jadoul M, Gatto L, Bommer GT, Morelle J (2022). Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19. Sci Rep. 12(1):9959. doi: 10.1038/s41598-022-14292-w.
5. Heremans IP, Caligiore F, Gerin I, Bury M, Lutz M, Graff J, Stroobant V, Vertommen D, Teleman AA, Van Schaftingen E, Bommer GT (2022). Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite. Proc Natl Acad Sci U S A. 119(4):e2111338119. doi: 10.1073/pnas.2111338119.
6. Clerbaux LA, Schultz H, Roman-Holba S, Ruan DF, Yu R, Lamb AM, Bommer GT, Kennell JA (2021). The microRNA miR-33 is a pleiotropic regulator of metabolic and developmental processes in Drosophila melanogaster. Developmental Dynamics. 250(11):1634-1650. doi: 10.1002/dvdy.344.
7. Dewulf JP, Paquay S, Marbaix E, Achouri Y, Van Schaftingen E, Bommer GT (2021). ECHDC1 knockout mice accumulate ethyl-branched lipids and excrete abnormal intermediates of branched-chain fatty acid metabolism. J Biol Chem. 297(4):101083. doi: 10.1016/j.jbc.2021.101083.
8. Morava E, Schatz UA, Torring PM, Abbott MA, Baumann M, Brasch-Andersen C, Chevalier N, Dunkhase-Heinl U, Fleger M, Haack TB, Nelson S, Potelle S, Radenkovic S, Bommer GT, Van Schaftingen E, Veiga-da-Cunha M (2021). Impaired glucose-1,6-biphosphate production due to bi-allelic PGM2L1 mutations is associated with a neurodevelopmental disorder. Am J Hum Genet. 108(6):1151-1160. doi: 10.1016/j.ajhg.2021.04.017. Epub 2021 May 11.
9. Ury B, Potelle S, Caligiore F, Whorton MR, Bommer GT (2021). The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi. J Biol Chem. 296:100789. doi: 10.1016/j.jbc.2021.100789.
10. Kentache T, Thabault L, Deumer G, Haufroid V, Frédérick R, Linster CL, Peracchi A, Veiga-da-Cunha M, Bommer GT, Van Schaftingen E (2021). The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate. J Biol Chem. 2021 100699. doi: 10.1016/j.jbc.2021.100699. Epub 2021 Apr 23.
11. Darius T, Vergauwen M, Smith T, Gerin I, Joris V, Mueller M, Aydin S, Muller X, Schlegel A, Nath J, Ludwig C, Dessy C, Many MC, Bommer G, Dutkowski P, Gianello P, Mourad M (2020). Brief O2 uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model. Am J Transplant. 20(8):2030-2043. doi: 10.1111/ajt.15800.
12. Kentache T, Thabault L, Peracchi A, Frédérick R, Bommer GT, Van Schaftingen E. The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases. Bioscience Reports. 40(6):BSR20200927. doi: 10.1042/BSR20200927.
13. Bommer GT, Van Schaftingen E, Veiga-da-Cunha M (2020). Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis. Trends Biochemical Sciences. 45(3):228-243. doi: 10.1016/j.tibs.2019.07.004..
14. Veiga-da-Cunha M, Van Schaftingen E, Bommer GT (2020). Inborn errors of metabolite repair. J Inherited Metabolic Diseases. 43(1):14-24. doi: 10.1002/jimd.12187.
15. Marbaix AY, Chehade G, Noël G, Morsomme P, Vertommen D, Bommer GT, Van Schaftingen E (2019). Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Biochemical Journal. 476(20):3033-3052. doi: 10.1042/BCJ20190602.
16. Dewulf JP, Gerin I, Rider MH, Veiga-da-Cunha M, Van Schaftingen E, Bommer GT (2019). The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Biochemical Journal. 476(16):2427-2447. doi: 10.1042/BCJ20190500.
17. Gerin I, Bury M, Baldin F, Graff J, Van Schaftingen E, Bommer GT (2019). Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines. Biochemical Journal. 476(4):629-643. doi: 10.1042/BCJ20180435.
18. Veiga-da-Cunha M, Chevalier N, Stephenne X, Defour JP, Paczia N, Ferster A, Achouri Y, Dewulf JP, Linster CL, Bommer GT, Van Schaftingen E (2019). Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proc Natl Acad Sci U S A. 116(4):1241-1250. doi: 10.1073/pnas.1816143116. Epub 2019 Jan 9.
19. Wiame E, Tahay G, Tyteca D, Vertommen D, Stroobant V, Bommer GT, Van Schaftingen E. NAT6 acetylates the N-terminus of different forms of actin. FEBS J. 285(17):3299-3316. doi: 10.1111/febs.14605.
20. Peracchi A, Veiga-da-Cunha M, Kuhara T, Ellens KW, Paczia N, Stroobant V, Seliga AK, Marlaire S, Jaisson S, Bommer GT, Sun J, Huebner K, Linster CL, Cooper AJL, Van Schaftingen E (2017). Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proc Natl Acad Sci U S A. 114(16):E3233-E3242. doi: 10.1073/pnas.1613736114.
21. Bommer GT, Baldin F, Van Schaftingen E (2016). Accumulation of metabolic side products might favor the production of ethanol in Pho13 knockout strains. Microbial Cell. 3(10):495-499. doi: 10.15698/mic2016.10.532.
22. Gerin I, Ury B, Breloy I, Bouchet-Seraphin C, Noel G, Bolsee J, Halbout M, Graff J, Vertommen D, Muccioli GG, Seta N, Grahn A, Van Schaftingen E, Bommer GT (2016). ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol-phosphate onto a-dystroglycan. Nature communications 7(11534. doi.
23. Collard F, Baldin F, Gerin I, Bolsee J, Noel G, Graff J, Veiga-da-Cunha M, Stroobant V, Vertommen D, Houddane A, Rider MH, Linster CL, Van Schaftingen E, Bommer GT (2016). A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Nature chemical biology 12(601-607. doi: 10.1038/nchembio.2104.
24. Arts N, Cane S, Hennequart M, Lamy J, Bommer G, Van den Eynde B, De Plaen E (2015). microRNA-155, induced by interleukin-1ss, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. PLoS One 10(4): e0122517. doi: 10.1371/journal.pone.0122517.
25. Gerin I, Noel G, Bolsee J, Haumont O, Van Schaftingen E, Bommer GT (2014). Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase. The Biochemical journal 458(3): 439-448. doi: 10.1042/BJ20130841.
26. Pachikian BD, Essaghir A, Demoulin JB, Catry E, Neyrinck AM, Dewulf EM, Sohet FM, Portois L, Clerbaux LA, Carpentier YA, Possemiers S, Bommer GT, Cani PD, Delzenne NM (2013). Prebiotic approach alleviates hepatic steatosis: implication of fatty acid oxidative and cholesterol synthesis pathways. Molecular nutrition & food research 57(2): 347-359. doi: 10.1002/mnfr.201200364.
27. Gauthy E, Cuende J, Stockis J, Huygens C, Lethe B, Collet JF, Bommer G, Coulie PG, Lucas S (2013). GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells. PLoS One 8(9): e76186. doi: 10.1371/journal.pone.0076186.
28. Feng Y, Sentani K, Wiese A, Sands E, Green M, Bommer GT, Cho KR, Fearon ER (2013). Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation. Am J Pathol 183(2): 493-503. doi: 10.1016/j.ajpath.2013.04.013.
29. Linster CL, Noel G, Stroobant V, Vertommen D, Vincent MF, Bommer GT, Veiga-da-Cunha M, Van Schaftingen E (2011). Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading. J Biol Chem 286(50): 42992-43003. doi: 10.1074/jbc.M111.281527.
30. Feng Y, Bommer GT, Zhao J, Green M, Sands E, Zhai Y, Brown K, Burberry A, Cho KR, Fearon ER (2011). Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool. Gastroenterology 141(3): 1003-1013 e1001-1010. doi: 10.1053/j.gastro.2011.05.007.
31. Bommer GT, MacDougald OA (2011). Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus. Cell metabolism 13(3): 241-247. doi.
32. Bommer GT, Fearon ER (2011). Ancestries Hidden in Plain Sight - Methylation Patterns for Clonal Analysis. Gastroenterology. doi.
33. Bommer GT, Fearon ER (2011). Wnt/β-catenin Signaling in the Gastrointestinal Tract. In: Johnson LR, Wood JD, Barrett KE, Ghishan FK, Merchant JL, editors. Physiology of the Gastrointestinal tract. Elsevier Academic Press; pp.
34. Zhai Y, Bommer GT, Feng Y, Wiese AB, Fearon ER, Cho KR (2010). Loss of estrogen receptor 1 enhances cervical cancer invasion. Am J Pathol 177(2): 884-895. doi: ajpath.2010.091166 [pii] 10.2353/ajpath.2010.091166.
35. Reka AK, Kurapati H, Narala VR, Bommer G, Chen J, Standiford TJ, Keshamouni VG (2010). Peroxisome proliferator-activated receptor-{gamma} activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition. Mol Cancer Ther 9(12): 3221-3232. doi: 9/12/3221 [pii] 10.1158/1535-7163.MCT-10-0570.
36. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT (2010). Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem 285(44): 33652-33661. doi: M110.152090 [pii] 10.1074/jbc.M110.152090.
37. Gerin I, Bommer GT, McCoin CS, Sousa KM, Krishnan V, MacDougald OA (2010). Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis. Am J Physiol Endocrinol Metab 299(2): E198-206. doi: ajpendo.00179.2010 [pii] 10.1152/ajpendo.00179.2010.
38. Bommer GT, Feng Y, Iura A, Giordano TJ, Kuick R, Kadikoy H, Sikorski D, Wu R, Cho KR, Fearon ER (2010). IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype. J Biol Chem 285(3): 1928-1938. doi: M109.060319 [pii] 10.1074/jbc.M109.060319.
39. Rowe RG, Li XY, Hu Y, Saunders TL, Virtanen I, Garcia de Herreros A, Becker KF, Ingvarsen S, Engelholm LH, Bommer GT, Fearon ER, Weiss SJ (2009). Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol 184(3): 399-408. doi: jcb.200810113 [pii] 10.1083/jcb.200810113.
40. Ji Q, Hao X, Zhang M, Tang W, Yang M, Li L, Xiang D, Desano JT, Bommer GT, Fan D, Fearon ER, Lawrence TS, Xu L (2009). MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One 4(8): e6816. doi: 10.1371/journal.pone.0006816.
41. Herbst A, Bommer GT, Kriegl L, Jung A, Behrens A, Csanadi E, Gerhard M, Bolz C, Riesenberg R, Zimmermann W, Dietmaier W, Wolf I, Brabletz T, Goke B, Kolligs FT (2009). ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition. Gastroenterology 137(2): 639-648, 648 e631-639. doi: S0016-5085(09)00606-4 [pii] 10.1053/j.gastro.2009.04.049.
42. Gerin I, Bommer GT, Lidell ME, Cederberg A, Enerback S, Macdougald OA (2009). On the role of FOX transcription factors in adipocyte differentiation and insulin-stimulated glucose uptake. J Biol Chem 284(16): 10755-10763. doi: M809115200 [pii] 10.1074/jbc.M809115200.
43. Fearon ER, Bommer GT (2008). Progressing from Gene Mutations to Cancer. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, editors. Abeloff's Clinical Oncology. Churchill Livingstone Elsevier, Philadelphia pp 207-222.
44. Fearon ER, Bommer GT (2008). Molecular biology of colorectal cancer. In: DeVita VTJ, Lawrence TS, Rosenberg SA, editors. Cancer: Principles & Practise of Oncology. Lippincott Williams & Wilkins, Philadelphia; pp.
45. Bommer GT, Fearon ER (2008). Molecular Alterations in colorectal cancer. In: Mendelsohn J, Howley PM, Israel MA, Gray JW, Thompson CB, editors. Molecular Basis of Cancer. Saunders, Philadelphia; pp 289-312.
46. Akyol A, Hinoi T, Feng Y, Bommer GT, Glaser TM, Fearon ER (2008). Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene. Nat Methods 5(3): 231-233. doi: nmeth.1182 [pii] 10.1038/nmeth.1182.
47. Feng Y, Bommer GT, Zhai Y, Akyol A, Hinoi T, Winer I, Lin HV, Cadigan KM, Cho KR, Fearon ER (2007). Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. Cancer Res 67(2): 482-491. doi: 67/2/482 [pii] 10.1158/0008-5472.CAN-06-2314.
48. Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, MacDougald OA, Cho KR, Fearon ER (2007). p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 17(15): 1298-1307. doi: S0960-9822(07)01638-7 [pii] 10.1016/j.cub.2007.06.068.
49. Bommer GT, Fearon ER (2007). Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning? Cancer Cell 11(5): 391-394. doi: S1535-6108(07)00121-3 [pii] 10.1016/j.ccr.2007.04.015.
50. Winer IS, Bommer GT, Gonik N, Fearon ER (2006). Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation. J Biol Chem 281(36): 26181-26187. doi: M604217200 [pii] 10.1074/jbc.M604217200.
51. Lenhard K, Bommer GT, Asutay S, Schauer R, Brabletz T, Goke B, Lamerz R, Kolligs FT (2005). Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer. Clin Gastroenterol Hepatol 3(2): 142-149. doi: S154235650400624X [pii].
52. Bommer GT, Jager C, Durr EM, Baehs S, Eichhorst ST, Brabletz T, Hu G, Frohlich T, Arnold G, Kress DC, Goke B, Fearon ER, Kolligs FT (2005). DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. J Biol Chem 280(9): 7962-7975. doi: M412593200 [pii] 10.1074/jbc.M412593200.